DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS (ENGLISH)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Ders Genel Tanıtım Bilgileri

Course Code:

1414321004

Ders İsmi:

Molecular Biology

Ders Yarıyılı:

Spring

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	2	4	7

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Necessary

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:	The goal of the course is to teach gene expression mechanisms of eukaryotes and prokaryotes.
Course Content:	Gene expression in prokaryotes and eukaryotes; transcription, regulatory elements and transcription factors, mRNA processing, genetic code, translation and functional protein synthesis by post-translational modifications.

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) At the end of the course students should be able to know mechanisms oftranscription, gene regulation, RNA processing and translation in bacteria & eukaryotes.
2) At the end of the course students should be able to explain how recent genomics and functional genomics advances are altering our views.
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
1) At the end of the course students should be able to explain how classic experiments have led to our current understandings about DNA replication, recombination, transcription.
Field Specific Competence
1) At the end of the course students should be able to apply molecular knowledge to understand and hypothesize about specific complex systems such as the HIV retrovirus and human disease states with underlying molecular dysfunction.
2) At the end of the course students should be able to interpret the results of experiments using standard molecular techniques such as gel shift, transcription run-on assay, linker scanning promoter analysis, etc.
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Gene expression in prokaryotes	Textbook and Lecture notes
2)	Gene expression in eukaryotes	Textbook and Lecture notes
3)	Transcription in prokaryotes, its activation and repression and transcription factors	Textbook and Lecture notes
4)	Transcription in prokaryotes, its activation and repression and transcription factors	Textbook and Lecture notes
5)	Transcription in eukaryotes, its activation and repression and transcription factors	Textbook and Lecture notes
6)	Transcription in eukaryotes, its activation and repression and transcription factors	Textbook and Lecture notes
7)	RNA processing	Textbook and Lecture notes
8)	Midterm
9)	mRNA Stability and Localization	Textbook and Lecture notes
10)	Catalytic RNA and Regulatory RNA	Textbook and Lecture notes
11)	/Genetic code	Textbook and Lecture notes
12)	Translation in prokaryotes, structure and function of tRNA, ribosomes and regulatory proteins	Textbook and Lecture notes
13)	Translation in eukaryotes, structure and function of tRNA, ribosomes and regulatory proteins	Textbook and Lecture notes
14)	Post-translational modifications	Textbook and Lecture notes
15)	Final

Sources

Course Notes / Textbooks:	Genes VIII, Benjamin Lewin, New Jersey: Prentice- Hall, 2004. Molecular Biology of the Gene, James D. Watson, Tania A. Baker, Stephen P. Bell , Alexander Gann , Michael Levine , Richard Losick, Benjamin Cummings Pub Co., San Francisco, 2003
References:	Genes VIII, Benjamin Lewin, New Jersey: Prentice- Hall, 2004. Molecular Biology of the Gene, James D. Watson, Tania A. Baker, Stephen P. Bell , Alexander Gann , Michael Levine , Richard Losick, Benjamin Cummings Pub Co., San Francisco, 2003

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3	4	5
Program Outcomes
1) PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics
2) PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3) PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4) PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics
5) PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6) PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
7) PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product
8) PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods
9) PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10) PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11) PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications
12) PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics
13) PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.
14) PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15) PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16) PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17) PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18) PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics	4
2)	PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3)	PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4)	PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics	5
5)	PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6)	PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics	4
7)	PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product	5
8)	PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods	3
9)	PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10)	PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11)	PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications	3
12)	PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics	4
13)	PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.	5
14)	PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15)	PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16)	PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17)	PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18)	PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects	5

Öğrenme Etkinliği ve Öğretme Yöntemleri

Anlatım
Course
Labs
Homework

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Homework
Uygulama
Raporlama

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Laboratory	13	% 10
Midterms	1	% 30
Semester Final Exam	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	13	3	39
Laboratory	13	2	26
Application	13	2	26
Study Hours Out of Class	13	4	52
Homework Assignments	10	2	20
Quizzes	7	2	14
Total Workload			177