MEDICAL BIOCHEMISTRY (MEDICINE) (MASTER) (WITH THESIS)
Qualification Awarded	Program Süresi	Toplam Kredi (AKTS)	Öğretim Şekli	Yeterliliğin Düzeyi ve Öğrenme Alanı
Master's ( Second Cycle) Degree	2	120	FULL TIME	TYÇ, TR-NQF-HE, EQF-LLL, ISCED (2011):Level 7 QF-EHEA:Second Cycle TR-NQF-HE, ISCED (1997-2013): 72

Ders Genel Tanıtım Bilgileri

Course Code:

3027002003

Ders İsmi:

Cancer Biochemistry and Oncogenes

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Labs	Credit	ECTS
3	0	0	3	6

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Other Recommended Topics for the Course:

None

Type of course:

Anabilim Dalı/Lisansüstü Seçmeli

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Hafize UZUN

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:

The aim of this course is to provide an understanding of the biochemical foundations of cancer and focus on the role of cancer development, progression, and response to treatment. Students will be taught the roles of oncogenes, tumor suppressor genes, cellular pathways, and molecular mechanisms in cancer development, leading to a comprehensive understanding of cancer biology. Additionally, biochemical perspectives on cancer diagnosis and treatment methods will also be discussed.

Course Content:

This course aims to explore the biochemical foundations of cancer and the role of oncogenes. It will cover fundamental biochemical processes such as metabolic changes in cancer cells, the cell cycle, apoptosis, and genetic and epigenetic alterations. The role of oncogenes and tumor suppressor genes in cancer development, molecular pathways of cancer, and mechanisms of metastasis will be examined in detail. The course will also emphasize the significance of biochemical targets in cancer treatment, immunotherapies, and targeted therapies.

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) The learning outcomes of this course include understanding the basic principles of cancer biochemistry and oncogenes, grasping the molecular foundations of cancer, and relating this knowledge to clinical applications. Students will gain the ability to analyze the biochemical processes, genetic and epigenetic changes in cancer, and identify critical factors in cancer development and treatment. Additionally, they will enhance their analytical thinking skills by applying the knowledge in research projects and group discussions.
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
1) In this course, students will gain an in-depth understanding of the role of cancer biochemistry and oncogenes in cancer development. They will focus on the biochemical changes at the cellular level, cancer metastasis, and response to treatment. Additionally, students will explore the biochemical and molecular approaches used in cancer treatment, enabling them to assess the effectiveness of these strategies. The course will also help students develop scientific thinking and critical analysis skills by investigating the biological and molecular dynamics of cancer.
Field Specific Competence
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Markers related to multiple myeloma	Thyroid Stimulating Hormone Receptor. Yazar:Tuncel, Murat
1)	Biyokimya kanseri teşhisi ve tedavisi	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
2)	Overview of tumor markers	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
3)	α- fetoprotein	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
4)	Growth factors in cancer	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
5)	Growth factors receptors	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
6)	Serum and urine markers in prostate cancer	İnsan tümör hücre dizilerinde MDR1/P-170 ve MRP1/P-190 aktivitelerinin incelenmesi Yazar:Doğan, Ayşe Lale
7)	Cancer diagnosis and treatment in terms of biochemistry	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
8)	Mid-Term
9)	Gastrointestinal system tumor markers	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
10)	Tumor markers in lymphomas	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
11)	Gynecological tumor markers	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
12)	Tumor markers in leukemias	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
13)	Tumor markers in thyroid and parathyroid cancers	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
14)	Circulating tumor cells	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
15)	Biyokimya yönünden kanser teşhisi ve tedavisi	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
15)	Biyokimya yönünden kanser teşhisi ve tedavisi	CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker
16)	Final Exams

Sources

Course Notes / Textbooks:

Dersin opsiyonel bileşenleri, öğrencilerin konuya derinlemesine hâkim olmalarını sağlamayı hedefler. Seminer ve grup çalışmaları, öğrencilerin kanser biyokimyası ve onkogenler hakkında yaptıkları araştırmaları tartışmalarına imkân tanır, böylece analitik düşünme ve problem çözme becerileri geliştirilir. Ayrıca, öğrenciler özgün bir araştırma projesi geliştirerek bilimsel yazım, veri analizi ve sunum becerilerini güçlendirirler. Konuk konuşmacılar ve klinik vaka analizleri, öğrencilere kanser araştırmaları ve tedavi yaklaşımları hakkında gerçek dünya perspektifleri sunar. Ders ayrıca, biyokimyasal tedavi yöntemlerini pekiştirmek amacıyla laboratuvar çalışmaları da içerir; bu sayede öğrenciler, teorik bilgilerini pratik uygulamalarla birleştirerek deneyim kazanırlar.

References:

CANCER BIOCHEMISTRY Yazar:Yokuş, Beran; Çakır, Dilek Ülker

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2
Program Outcomes
1) Upon successful completion of the Medical Biochemistry Master's Program (Thesis), students will gain the following knowledge, skills, and competencies: In-Depth Knowledge in Biochemistry: Students will gain advanced knowledge in biochemistry, molecular biology, and biotechnology, understanding fundamental principles in the health sciences and medical biochemistry fields. Research and Analytical Skills: Students will acquire the ability to perform biochemical analyses in modern biochemistry laboratories, analyze experimental data, and derive scientific conclusions. Scientific Thinking and Problem-Solving: Students will develop the ability to identify and solve complex biochemical problems and generate innovative solutions through scientific thinking. Academic Writing and Presentation Skills: Students will be capable of presenting research results clearly, understandably, and scientifically in both written and oral formats. Ethical and Scientific Responsibility: Students will develop an understanding of ethical conduct in research, scientific responsibility, and integrity. Advanced Research Skills: Students will gain the ability to review scientific literature, develop new research questions, and design original research projects. International Scientific Collaboration: Students will gain the ability to participate in international scientific projects and conduct research on a global scale. Multidisciplinary Work: Students will acquire the ability to work with a multidisciplinary approach by combining knowledge from fields like biochemistry and medicine.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Upon successful completion of the Medical Biochemistry Master's Program (Thesis), students will gain the following knowledge, skills, and competencies: In-Depth Knowledge in Biochemistry: Students will gain advanced knowledge in biochemistry, molecular biology, and biotechnology, understanding fundamental principles in the health sciences and medical biochemistry fields. Research and Analytical Skills: Students will acquire the ability to perform biochemical analyses in modern biochemistry laboratories, analyze experimental data, and derive scientific conclusions. Scientific Thinking and Problem-Solving: Students will develop the ability to identify and solve complex biochemical problems and generate innovative solutions through scientific thinking. Academic Writing and Presentation Skills: Students will be capable of presenting research results clearly, understandably, and scientifically in both written and oral formats. Ethical and Scientific Responsibility: Students will develop an understanding of ethical conduct in research, scientific responsibility, and integrity. Advanced Research Skills: Students will gain the ability to review scientific literature, develop new research questions, and design original research projects. International Scientific Collaboration: Students will gain the ability to participate in international scientific projects and conduct research on a global scale. Multidisciplinary Work: Students will acquire the ability to work with a multidisciplinary approach by combining knowledge from fields like biochemistry and medicine.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Akran Değerlendirmesi
Anlatım
Beyin fırtınası /Altı şapka
Bireysel çalışma ve ödevi
Course
Grup çalışması ve ödevi
Labs
Okuma
Homework
Problem Çözme
Proje Hazırlama
Rapor Yazma
Rol oynama
Seminar
Soru cevap/ Tartışma
Sosyal Faaliyet
Teknik gezi
Tez Hazırlama
Uygulama (Modelleme, Tasarım, Maket, Simülasyon, Deney vs.)
Örnek olay çalışması
Web Tabanlı Öğrenme
Staj/Yerinde Uygulama

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Sözlü sınav
Homework
Uygulama
Gözlem
Bireysel Proje
Grup Projesi
Sunum
Raporlama
Akran Değerlendirmesi
Bilgisayar Destekli Sunum
Tez Sunma
Uzman / Jüri Değerlendirmesi
Örnek olay sunma
Staj/ Yerinde Uygulama Değerlendirmesi
Yarışma

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Midterms	1	% 40
Semester Final Exam	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	14	3	42
Midterms	1	2	2
Final	1	2	2
Total Workload			46