MOLECULAR BIOLOGY AND GENETICS (MASTER) (WHIT THESIS)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Ders Genel Tanıtım Bilgileri

Course Code:

3015002028

Ders İsmi:

Intracellular Signaling

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	0	3	7

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Anabilim Dalı/Lisansüstü Seçmeli

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:

In this course, the intracellular signal transduction mechanisms, different types of receptors and functional properties of intracellular signaling pathways (G proteins, effector enzymes, ion channels, intracellular calcium, phospholipases and eicosanoids, protein kinases, protein phosphorylation, etc.), mechanisms that mediate the regulation of target cell responses, physiological functions of cell signaling (apoptosis, cell cycle regulation, gene transcription) and clinical significance (cancer, cardiovascular disease, learning and memory, immune respons) of signal transduction issues is intended to give an overview and understanding.

Course Content:

1. Mechanisms of signal transduction 2. Molecules involved in signal transduction • G proteins • Effector enzymes • Ion channels • Intracellular calcium • Phospholipases and eicosanoids • Protein kinases and protein phosphorylation 3. Cell surface receptors 4. Cell surface receptors for intracellular signal transduction • Type of receptors • Type of ligand molecules • Ion channels and neurotransmitters • Mechanisms of ion pump 5. Functional properties of signaling pathways 6. Cytoplasmic signaling pathways • Cytoplasmic secondary messengers • Function of secondary messengers in transduction pathways • cAMP and cGMP • Function of calcium-calmodulin in cell 7. Mechanisms for regulation of target cell responses 8.Signaling mechanisms controlling cell proliferation and differentiation • Ras signaling pathway • ERK / MAP kinases pathway 9.Signal transduction and physiological properties • Aging and telomerase • Apoptosis • Proteolytic mechanisms 10.Clinical importance of signal transduction • Cancer • Cardiovascular diseases • Learning and memory • Immun responses

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) Students will learn the cell signal transduction, signal types, and recognize the different characteristics of the signaling molecules.
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
1) Students will be learn the details in the different signaling pathways and related diseases.
Field Specific Competence
1) Students learn the relationships between the different signaling pathways, and thus their own research in different diseases, basing on the information they have acquired in this course to design and interpret the results obtained from research.
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Introduction to signal transduction	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
2)	Cellular signaling mechanisms	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
3)	Molecules involved in signal transduction -1	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
4)	Molecules involved in signal transduction -2	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
5)	Cell surface receptors for cell signaling molecules	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
6)	Intracellular signal transduction	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
7)	Functional properties of signaling pathways-2	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
8)	Midterm exam
9)	Mechanisms for regulation of target cell responses -1	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
10)	Signaling mechanisms controlling cell proliferation and differentiation	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
11)	Signal transduction and physiological properties	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
12)	Signal transduction and cancer	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
13)	Signal transduction and cardiovascular diseases, immun response, learning and memory	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
14)	Signal transduction and cardiovascular diseases, immun response, learning and memory	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
15)	Recent Literature Discussion
16)	Final exam

Sources

Course Notes / Textbooks:	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.
References:	D.L. Nelson, M.M.Cox, Lehninger Principles of Biochemistry, Worth Publisher, 6th Edition, 2013.

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2) Use of advanced theoretical and practical knowledge within the field.
3) Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4) Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5) Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6) Organize and implement project and activities for social environment with a sense of social responsibility.
7) Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8) Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9) Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10) Determine learning needs and direct the learning.
11) Develop positive attitude towards lifelong learning.
12) Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13) Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14) Conduct studies at an advanced level in the field independently.
15) Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16) Planning and managing activities towards the development of subordinates in the framework of a project.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2)	Use of advanced theoretical and practical knowledge within the field.
3)	Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4)	Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5)	Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6)	Organize and implement project and activities for social environment with a sense of social responsibility.
7)	Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8)	Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9)	Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10)	Determine learning needs and direct the learning.
11)	Develop positive attitude towards lifelong learning.
12)	Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13)	Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14)	Conduct studies at an advanced level in the field independently.
15)	Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16)	Planning and managing activities towards the development of subordinates in the framework of a project.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Course
Okuma

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Homework
Gözlem

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	15	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Study Hours Out of Class	15	5	75
Presentations / Seminar	15	2	30
Homework Assignments	15	3	45
Quizzes	15	1	15
Midterms	1	2	2
Final	1	3	3
Total Workload			200