MOLECULAR BIOLOGY AND GENETICS (MASTER) (WHIT THESIS)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Ders Genel Tanıtım Bilgileri

Course Code:

3015002026

Ders İsmi:

Advanced Studies in RNA Biology

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	0	3	7

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Anabilim Dalı/Lisansüstü Seçmeli

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:	The aim of this course is to provide information related to RNA types in the RNA world and which pathways they play roles.
Course Content:	Non-coding RNAs, discovery of miRNA, siRNA and lncRNA sequences, how these sequences are produced, their relationships in the regulation of gene expression, their relationships with the ribosome, their useage in disease treatments

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) Will have knowledge about non-coding RNAs.
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
1) Will understand the relationships betweem different mechanisms and RNAs.
Field Specific Competence
1) Will understand the use of RNAs in the treatment of stress-related diseases in different organisms.
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Introduction to RNA World	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
2)	The Discovery of miRNAs as Gene Regulators	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
3)	The Other Roles of miRNAs	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
4)	The Discovery of siRNAs as Therapeutic Agent	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
5)	Circular RNAs and Competing Endogenous RNA Hypothesis	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
6)	Role of lncRNAs in X Chromosome Inactivation	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
7)	Role of lncRNAs in X Genomic Imprinting	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
8)	Midterm
9)	Project presentation related to miRNA, siRNA and lncRNA	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
10)	Project presentation related to miRNA, siRNA and lncRNA 2	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
11)	Catalytic Functions of RNA and RNA-World Hypothesis: Ribozymes	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
12)	The Relationships between RNA-Ribozom	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
13)	Chemical Modifications of Mature RNA Molecules	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
14)	RNA-guided Immune System to Treat Human Disease	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
15)	Recent Literature Discussion
16)	Final exam

Sources

Course Notes / Textbooks:	Rao, M. R. S. (Ed.). (2017). Long Non Coding RNA Biology (Vol. 1008). Springer. Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation. Bu konu ile ilgili derleme ve araştırma makaleleri
References:	Rao, M. R. S. (Ed.). (2017). Long Non Coding RNA Biology (Vol. 1008). Springer. Atkins, J. F., Gesteland, R. F., Reviews and research articles related to this topic.

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2) Use of advanced theoretical and practical knowledge within the field.
3) Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4) Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5) Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6) Organize and implement project and activities for social environment with a sense of social responsibility.
7) Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8) Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9) Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10) Determine learning needs and direct the learning.
11) Develop positive attitude towards lifelong learning.
12) Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13) Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14) Conduct studies at an advanced level in the field independently.
15) Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16) Planning and managing activities towards the development of subordinates in the framework of a project.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2)	Use of advanced theoretical and practical knowledge within the field.
3)	Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4)	Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5)	Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6)	Organize and implement project and activities for social environment with a sense of social responsibility.
7)	Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8)	Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9)	Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10)	Determine learning needs and direct the learning.
11)	Develop positive attitude towards lifelong learning.
12)	Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13)	Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14)	Conduct studies at an advanced level in the field independently.
15)	Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16)	Planning and managing activities towards the development of subordinates in the framework of a project.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Course

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Sözlü sınav
Grup Projesi
Sunum

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	15	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Study Hours Out of Class	15	5	75
Presentations / Seminar	15	2	30
Homework Assignments	15	3	45
Quizzes	15	1	15
Midterms	1	2	2
Final	1	3	3
Total Workload			200