MOLECULAR BIOLOGY AND GENETICS (MASTER) (WHIT THESIS)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Ders Genel Tanıtım Bilgileri

Course Code:

3015002025

Ders İsmi:

Advanced Cancer Biology

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	0	3	7

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Anabilim Dalı/Lisansüstü Seçmeli

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:

This course aims to educate students on various genetic and molecular changes normal cells undergo during transformation into malignant cancer cells.

Course Content:

Introduction to cancer biology; DNA structure and stability: mutations versus repair; Regulation of gene expression; Growth factor signaling and oncogenes; The cell cycle; Growth inhibition and tumor suppressor genes; Apoptosis; Stem cells and differentiation; Metastasis; The immune system, infections, and inflammation; Nutrients, hormones, and gene interactions; The cancer industry: drug development, pharmacogenomics, and clinical trial design; Cancer in the future

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) To give students a general perspective about cancer biology.
2 - Skills
Cognitive - Practical
1) To understand the cellular and molecular basis of current strategies for cancer prevention and treatment.
3 - Competences
Communication and Social Competence
Learning Competence
Field Specific Competence
1) To develop fundamental concepts of cancer identification, etiology and epidemiology.
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Introduction to cancer biology	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
2)	DNA structure and stability: mutations versus repair	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
3)	Regulation of gene expression, epigenetic regulation of transcription, role of epigenetics in carcinogenesis	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
4)	Growth factor signaling and oncogenes, kinase inhibitors, oncogene activation and therapeutic strategies	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
5)	The cell cycle, relation between cell cycle and cancer	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
6)	Growth inhibition and tumor suppressor genes	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
7)	Apoptosis and cancer	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
8)	Midterm	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
9)	Apoptosis and cancer	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
10)	Metastasis	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
11)	The immune system, infections, and inflammation	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
12)	Nutrients, hormones, and gene interactions	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
13)	The cancer industry: drug development, pharmacogenomics, and clinical trial design	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
14)	Cancer in the future	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
15)	Recent Publication Discussion
16)	Final exam

Sources

Course Notes / Textbooks:	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012 The Biology of Cancer, R. A. Weinberg, Garland Science, 2007
References:	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012 The Biology of Cancer, R. A. Weinberg, Garland Science, 2007

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2) Use of advanced theoretical and practical knowledge within the field.
3) Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4) Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5) Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6) Organize and implement project and activities for social environment with a sense of social responsibility.
7) Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8) Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9) Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10) Determine learning needs and direct the learning.
11) Develop positive attitude towards lifelong learning.
12) Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13) Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14) Conduct studies at an advanced level in the field independently.
15) Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16) Planning and managing activities towards the development of subordinates in the framework of a project.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2)	Use of advanced theoretical and practical knowledge within the field.
3)	Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4)	Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5)	Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6)	Organize and implement project and activities for social environment with a sense of social responsibility.
7)	Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8)	Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9)	Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10)	Determine learning needs and direct the learning.
11)	Develop positive attitude towards lifelong learning.
12)	Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13)	Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14)	Conduct studies at an advanced level in the field independently.
15)	Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16)	Planning and managing activities towards the development of subordinates in the framework of a project.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Course
Seminar

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Homework
Gözlem
Sunum
Raporlama

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	15	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	3	45
Study Hours Out of Class	15	5	75
Homework Assignments	15	4	60
Quizzes	10	2	20
Midterms	1	2	2
Final	1	2	2
Total Workload			204