MOLECULAR BIOLOGY AND GENETICS (MASTER) (WHIT THESIS)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Ders Genel Tanıtım Bilgileri

Course Code:

3015002022

Ders İsmi:

Genome and Epigenetics

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	0	3	7

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Anabilim Dalı/Lisansüstü Seçmeli

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:	The aim of this course help the students learn genome structure, genome organization and genetic and epigenetic changes of gene expression.
Course Content:	Genome Anatomies, Studying Genome, How Genomes Function, Regulation of Genome Activity, DNA Methylation, Histone Modifications and Epigenetics, Non-coding RNAs in Gene Regulation, The Biology of Genomic Imprinting, X Chromosome Inactivation.

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) By the end of the course the students will have detailed knowledge about genome structure and genome organization.
2 - Skills
Cognitive - Practical
1) Students will be able to describe the change mechanisms of gene expression.
3 - Competences
Communication and Social Competence
Learning Competence
1) Students will learn the role of the epigenetic changes on organisms.
Field Specific Competence
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Students will learn the role of the epigenetic changes on organisms.	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
2)	How Genomes Function, Regulation of Genome Activity	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
3)	DNA Methylation and the Genome	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
4)	DNA Methylation Changes in Cancer	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
5)	Genome-Wide and Gene-Specific Analysis of DNA Methylation Levels and Patterns	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
6)	Histone Modifications and Epigenetics	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
7)	Histone Variants and Nucleosome Occupancy	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
8)	Midterm exam
9)	Non-coding RNAs in Gene Regulation	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
10)	The Biology of Genomic Imprinting	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
11)	The Molecular Mechanisms of Mammalian X Inactivation	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
12)	Cancer Epigenetics	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
13)	The Impact of the Environment on Epigenetic Regulation of Gene Expression and Developmental Programming	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
14)	Plant Epigenetics	Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-
15)	Recent Publication Discussion
16)	Final Exam

Sources

Course Notes / Textbooks:

Genomes,2nd edit. Terence A Brown. Department of Biomolecular Sciences, UMIST, Manchester, UK Oxford: Wiley-Liss; 2002 Epigenetic, Jörg Tost CEA, Caister Academic Press, 2008 ISBN:978-1-904455-23-3 Epigenetic: A reference Manual, Jeffrey M. Craig and Nicholas C. Wong Caister Academic Press, March 2008, ISBN: 978-1-904455-88-2 Genomic Technologies: Present and Future, David J. Galas, 2002, ISBN: 978-0-9542464-2-

References:

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2) Use of advanced theoretical and practical knowledge within the field.
3) Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4) Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5) Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6) Organize and implement project and activities for social environment with a sense of social responsibility.
7) Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8) Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9) Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10) Determine learning needs and direct the learning.
11) Develop positive attitude towards lifelong learning.
12) Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13) Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14) Conduct studies at an advanced level in the field independently.
15) Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16) Planning and managing activities towards the development of subordinates in the framework of a project.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2)	Use of advanced theoretical and practical knowledge within the field.
3)	Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4)	Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5)	Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6)	Organize and implement project and activities for social environment with a sense of social responsibility.
7)	Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8)	Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9)	Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10)	Determine learning needs and direct the learning.
11)	Develop positive attitude towards lifelong learning.
12)	Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13)	Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14)	Conduct studies at an advanced level in the field independently.
15)	Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16)	Planning and managing activities towards the development of subordinates in the framework of a project.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Okuma

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Homework
Bireysel Proje

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	7	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Study Hours Out of Class	15	5	75
Presentations / Seminar	15	2	30
Homework Assignments	15	4	60
Midterms	1	2	2
Final	1	2	2
Total Workload			199