DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS (ENGLISH)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Ders Genel Tanıtım Bilgileri

Course Code:

1414002049

Ders İsmi:

RNA World

Ders Yarıyılı:

Spring

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
2	2	3	5

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Department Elective

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:	The aim of this course is to provide information related to RNA types in the RNA world and which pathways they play roles.
Course Content:	Non-coding RNAs, discovery of miRNA, siRNA and lncRNA sequences, how these sequences are produced, their relationships in the regulation of gene expression, their relationships with the ribosome, their useage in disease treatments

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) Will have knowledge about non-coding RNAs.
2 - Skills
Cognitive - Practical
1) Will understand the relationships betweem different mechanisms and RNAs.
3 - Competences
Communication and Social Competence
Learning Competence
1) Will understand the use of RNAs in the treatment of stress-related diseases in different organisms.
Field Specific Competence
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Introduction to RNA World	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
2)	The Discovery of miRNAs as Gene Regulators	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
3)	The Other Roles of miRNAs	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
4)	The Discovery of siRNAs as Therapeutic Agent	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
5)	Circular RNAs and Competing Endogenous RNA Hypothesis	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
6)	Role of lncRNAs in X Chromosome Inactivation	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
7)	Role of lncRNAs in X Genomic Imprinting	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
8)	Midterm exam
9)	Project presentation related to miRNA, siRNA and lncRNA	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
10)	Project presentation related to miRNA, siRNA and lncRNA 2	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
11)	Catalytic Functions of RNA and RNA-World Hypothesis: Ribozymes	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
12)	The Relationships between RNA-Ribozom	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
13)	Chemical Modifications of Mature RNA Molecules	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
14)	RNA-guided Immune System to Treat Human Disease	Atkins, J. F., Gesteland, R. F., & Cech, T. (Eds.). (2011). RNA worlds: from life's origins to diversity in gene regulation.
15)	Semester subject review
16)	Final exam

Sources

Course Notes / Textbooks:	Rao, M. R. S. (Ed.). (2017). Long Non Coding RNA Biology (Vol. 1008). Springer. Atkins, J. F., Gesteland, R. F., Reviews and research articles related to this topic.
References:	Rao, M. R. S. (Ed.). (2017). Long Non Coding RNA Biology (Vol. 1008). Springer. Atkins, J. F., Gesteland, R. F., Reviews and research articles related to this topic.

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics
2) PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3) PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4) PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics
5) PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6) PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
7) PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product
8) PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods
9) PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10) PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11) PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications
12) PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics
13) PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.
14) PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15) PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16) PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17) PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18) PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics
2)	PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3)	PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4)	PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics
5)	PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6)	PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
7)	PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product
8)	PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods
9)	PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10)	PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11)	PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications
12)	PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics
13)	PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.
14)	PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15)	PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16)	PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17)	PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18)	PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Course
Homework

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Uygulama
Grup Projesi
Sunum

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Application	15	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Application	15	2	30
Study Hours Out of Class	15	4	60
Homework Assignments	15	2	30
Midterms	1	2	2
Final	1	2	2
Total Workload			154