MOLECULAR BIOLOGY AND GENETICS (MASTER) (WHIT THESIS)
Master	TR-NQF-HE: Level 7	QF-EHEA: Second Cycle	EQF-LLL: Level 7

Ders Genel Tanıtım Bilgileri

Course Code:

3015121001

Ders İsmi:

Advanced Molecular Genetics

Ders Yarıyılı:

Spring

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
3	0	3	9

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Necessary

Course Level:

Master

TR-NQF-HE:7. Master`s Degree

QF-EHEA:Second Cycle

EQF-LLL:7. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi Banu TAKTAK KARACA

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:

Learn the basic properties of nucleic acid molecules shaping the organism's genetic information, understanding the chromosomal organization and packaging in prokaryotic and eukaryotic organisms, understanding the mechanism of DNA replication, learning the transcription and translation in gene expression in prokaryotic and eukaryotic organisms with comparison between the organisms, learning the basics of genetic code, Understanding the relationship between genotype and phenotype in prokaryotic and eukaryotic organisms, learning the regulation of gene expression with respect to cellular differentiation and environmental conditions, understanding the mechanims of gene expression before transcription, during initiation of transcription, and initiation of translation, comprehension of the properties and roles of regulatory proteins in the regulation of gene expression, evaluating the gene control levels during cell signalig, embriyonic development, cancer and human genetic diseases.

Course Content:

Levels of Gene Control, Structure of Chromatin, Role of Chromatin Structure in Gene Control, The Process of Transcription, Transcription Factors and Transcription Control, Post-transcriptional Process and regulation, Gene Control and Cellular Signaling Pathway, Gene Control in Embriyonic Development,
Control of Cell-type specific gene expression, Gene Regulation and Cancer,
Gene Regulation and Human Diseases

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) Students should be able to explain how the structure and chemistry of DNA and RNA relate to their functions, their relative stability, and their interactions with proteins.
2 - Skills
Cognitive - Practical
3 - Competences
Communication and Social Competence
Learning Competence
Field Specific Competence
1) Students should be able to know the complete structures of DNA components, the different forms of DNA (A, B, Z) and relate DNA structure to forms of DNA damage.
2) Students should be able to compare & contrast mechanisms of DNA replication, repair, recombination.
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Levels of Gene Control	Textbook
2)	Structure of Chromatin	Textbook
3)	Role of Chromatin Structure in Gene Control	Textbook
4)	The Process of Transcription	Textbook
5)	Transcription Factors and Transcription Control	Textbook
6)	Post-transcriptional Process and Regulation	Textbook
7)	Midterm
8)	Gene Control and Cellular Signaling Pathway	Textbook
9)	Gene Control in Embriyonic Development	Textbook
10)	Control of Cell-type specific gene expression	Textbook
11)	Gene Regulation and Cancer	Textbook
12)	Gene Regulation and Human Diseases	Textbook
13)	Presentation	Presentation Preparation and Research
14)	Presentation	Presentation Preparation and Reseach
15)	Final Exam

Sources

Course Notes / Textbooks:	- Gene Control (2nd Edition), David S. Latchman, Garland Science, Taylor & Francis Group, 2015. - Molecular Biology of the Gene, 6th Edition, Watson, Baker, Bell, Gann, Levine, Losick, Pearson Publications, 2008. - Molecular Biology of RNA, Eliot, Ladomery, Oxford Publications, 2011.
References:	- Gene Control (2nd Edition), David S. Latchman, Garland Science, Taylor & Francis Group, 2015. - Molecular Biology of the Gene, 6th Edition, Watson, Baker, Bell, Gann, Levine, Losick, Pearson Publications, 2008. - Molecular Biology of RNA, Eliot, Ladomery, Oxford Publications, 2011

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2) Use of advanced theoretical and practical knowledge within the field.
3) Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4) Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5) Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6) Organize and implement project and activities for social environment with a sense of social responsibility.
7) Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8) Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9) Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10) Determine learning needs and direct the learning.
11) Develop positive attitude towards lifelong learning.
12) Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13) Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14) Conduct studies at an advanced level in the field independently.
15) Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16) Planning and managing activities towards the development of subordinates in the framework of a project.

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	Possess advanced level theoretical and practical knowledge supported by textbooks with updated information, practice equipments and other resources.
2)	Use of advanced theoretical and practical knowledge within the field.
3)	Interpret and evaluate data, define and analyze problems, develop solutions based on research and proofs by using acquired advanced knowledge and skills within the field.
4)	Inform people and institutions, transfer ideas and solution proposals to problems in written and orally on issues in the field.
5)	Share the ideas and solution proposals to problems on issues in the field with professionals and non-professionals by the support of qualitative and quantitative data.
6)	Organize and implement project and activities for social environment with a sense of social responsibility.
7)	Monitor the developments in the field and communicate with peers by using a foreign language at least at a level of European Language Portfolio B1 General Level.
8)	Use informatics and communication technologies with at least a minimum level of European Computer Driving License Advanced Level software knowledge.
9)	Evaluate the knowledge and skills acquired at an advanced level in the field with a critical approach.
10)	Determine learning needs and direct the learning.
11)	Develop positive attitude towards lifelong learning.
12)	Act in accordance with social, scientific, cultural and ethic values on the stages of gathering, implementation and release of the results of data related to the field.
13)	Possess sufficient consciousness about the issues of universality of social rights, social justice, quality, cultural values and also, environmental protection, worker's health and security.
14)	Conduct studies at an advanced level in the field independently.
15)	Take responsibility both as a team member and individually in order to solve unexpected complex problems faced within the implementations in the field.
16)	Planning and managing activities towards the development of subordinates in the framework of a project.

Öğrenme Etkinliği ve Öğretme Yöntemleri

Alan Çalışması
Anlatım
Course
Homework

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Homework
Uygulama
Sunum

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Homework Assignments	7	% 10
Midterms	1	% 30
Semester Final Exam	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	3	45
Study Hours Out of Class	15	5	75
Presentations / Seminar	10	3	30
Homework Assignments	15	3	45
Quizzes	13	3	39
Midterms	1	3	3
Paper Submission	15	2	30
Final	1	3	3
Total Workload			270