DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS (ENGLISH)
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Ders Genel Tanıtım Bilgileri

Course Code:

1414002022

Ders İsmi:

Molecular Biology of Cancer

Ders Yarıyılı:

Fall

Ders Kredileri:

Theoretical	Practical	Credit	ECTS
2	2	3	5

Language of instruction:

Ders Koşulu:

Ders İş Deneyimini Gerektiriyor mu?:

Type of course:

Department Elective

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Prof. Dr. Meliha Burcu IRMAK YAZICIOĞLU

Course Lecturer(s):

Course Assistants:

Dersin Amaç ve İçeriği

Course Objectives:

This course aims to educate students on various genetic and molecular changes normal cells undergo during transformation into malignant cancer cells

Course Content:

Introduction to cancer biology; DNA structure and stability: mutations versus repair; Regulation of gene expression; Growth factor signaling and oncogenes; Thecell cycle; Growth inhibition and tumor suppressor genes; Apoptosis; Stem cells and differentiation; Metastasis; The immune system, infections, and inflammation;Nutrients, hormones, and gene interactions; The cancer industry: drug development, pharmacogenomics, and clinical trial design; Cancer in the future

Learning Outcomes

The students who have succeeded in this course;

Learning Outcomes

1 - Knowledge
Theoretical - Conceptual
1) To give students a general perspective about cancer biology.
2 - Skills
Cognitive - Practical
1) To develop fundamental concepts of cancer identification, etiology and epidemiology.
3 - Competences
Communication and Social Competence
Learning Competence
1) To understand the cellular and molecular basis of current strategies for cancer prevention and treatment.
Field Specific Competence
Competence to Work Independently and Take Responsibility

Ders Akış Planı

Week	Subject	Related Preparation
1)	Introduction to cancer biology	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
2)	DNA structure and stability: mutations versus repair	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
3)	Regulation of gene expression, epigenetic regulation of transcription, role of epigenetics in carcinogenesis	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
4)	Growth factor signaling and oncogenes, kinase inhibitors, oncogene activation and therapeutic strategies	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
5)	The cell cycle, relation between cell cycle and cancer	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
6)	Growth inhibition and tumor suppressor genes	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
7)	Apoptosis and cancer	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
8)	Midterm
9)	Apoptosis and cancer
10)	Metastasis
11)	The immune system, infections, and inflammation	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
12)	Nutrients, hormones, and gene interactions	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
13)	The cancer industry: drug development, pharmacogenomics, and clinical trial design	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
14)	Cancer in the future	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
15)	Semester subject review
16)	Final exam

Sources

Course Notes / Textbooks:	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012
References:	Molecular Biology of Cancer, L. Pecorino, Oxford University Press, 2012

Ders - Program Öğrenme Kazanım İlişkisi

Ders Öğrenme Kazanımları	1	2	3
Program Outcomes
1) PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics
2) PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3) PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4) PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics
5) PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6) PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
7) PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product
8) PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods
9) PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10) PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11) PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications
12) PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics
13) PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.
14) PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15) PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16) PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17) PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18) PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects

Ders - Öğrenme Kazanımı İlişkisi

No Effect	1 Lowest	2 Low	3 Average	4 High	5 Highest

	Program Outcomes	Level of Contribution
1)	PÇ 1.1) To have sufficient knowledge required by the field of molecular biology and genetics
2)	PO 1.2) To be able to use the theoretical knowledge required by the field of molecular biology and genetics
3)	PO 1.3) To be able to apply the skills required by the field of molecular biology and genetics in the field
4)	PO 2.1) To be able to identify, define and interpret the problems in the field of Molecular Biology and Genetics
5)	PO 2.2) To be able to select appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
6)	PO 2.3) To be able to apply appropriate analysis and modeling methods to solve problems in the field of Molecular Biology and Genetics
7)	PO 3.1) To be able to understand and interpret any process, event, phenomenon, equipment or product
8)	PO 3.2) To be able to solve the problems encountered with appropriate and contemporary methods
9)	PO 4.) To be able to show interest in different disciplines outside the field for personal and professional development
10)	PO 5.1) To be able to select and use modern tools necessary for Molecular Biology and Genetics applications
11)	PO 5.2)To be able to use information technologies effectively for Molecular Biology and Genetics applications
12)	PO 6) To be able to design, experiment, field study, data collection, data analysis, reporting, archiving, text solving and/or interpretation in the field of Molecular Biology and Genetics
13)	PO 7) To be able to take responsibility as an individual and a team member, to produce solutions and to communicate well in unexpected complex situations that may be encountered in applications in the field of Molecular Biology and Genetics.
14)	PO 8.1) To be able to communicate effectively both orally and in writing in Turkish in order to plan academic studies in the field of Molecular Biology and Genetics and to carry out them independently or jointly with stakeholders
15)	PO 8.2) To be able to communicate orally and in writing in at least one foreign language in order to plan academic studies in the field of Molecular Biology and Genetics and to conduct them independently or jointly with stakeholders
16)	PO 9) To have the awareness of the necessity of lifelong learning, to have the ability to access information, to follow developments in science and technology and to have the ability to constantly renew oneself.
17)	PO 10) To have social, scientific, ethical values and awareness of protecting these values in the stages of collecting, interpreting, announcing and applying data related to the field of Molecular Biology and Genetics.
18)	PO 11) To be able to comprehend the universal and social effects of Molecular Biology and Genetics applications (environmental problems, economy, sustainability, etc.) and legal aspects

Öğrenme Etkinliği ve Öğretme Yöntemleri

Akran Değerlendirmesi
Anlatım
Course
Homework

Ölçme ve Değerlendirme Yöntemleri ve Kriterleri

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Sözlü sınav
Homework
Uygulama
Sunum
Akran Değerlendirmesi
Tez Sunma

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Application	15	% 20
Midterms	1	% 30
Semester Final Exam	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Duration (Hours)	Workload
Course Hours	15	2	30
Application	15	2	30
Study Hours Out of Class	15	4	60
Homework Assignments	15	2	30
Midterms	1	2	2
Final	1	2	2
Total Workload			154